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St. Petersburg, FL (Sports Network) - Matt Joyce hit a game-winning home run in the ninth inning as the Tampa Bay Rays defeated the Baltimore Orioles, 8-7, on Wednesday.

Shelley Duncan hit a three-run homer in the sixth inning, Ben Zobrist went 2- for-4 with two RBI and James Loney had a pinch-hit RBI double for the Rays, who lost their first game of the season.

Rays starter Jeremy Hellickson gave up five runs on eight hits in 6 1/3 innings, but did not earn the win.

Chris Davis was a perfect 4-for-4 with a three-run home run, two doubles and four RBI for the Orioles. Nate McLouth, Matt Wieters and Brian Roberts knocked in a run apiece in the setback.

Orioles starter Wei-Yin Chen allowed two runs on seven hits over 5 2/3 innings.