The "Medium" star will play Avery Ryan, the special agent in charge of the FBI's Cyber Crime Division in Quantico, Va., which is "tasked to solve high octane crimes that start in the mind, live online, and play out into the real world."
Avery will be introduced in a "CSI" episode later this spring, reports say.
Arquette, 45, starred on "Medium" from 2005-2011. She had an arc last year on HBO's "Boardwalk Empire" and her film credits include "True Romance," "Ed Wood," "Holes" and "Little Nicky."
By Jessica Derschowitz, CBS News
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