The 27-year-old actress will appear on the April 14 episode of the series, which is in its third season.
She'll portray Claire Guinness, a soon-to-be-bride who asks Max and Caroline to make her wedding cake. As Max and Caroline get to know her, they learn very quickly that Claire has trouble making decisions.
"2 Broke Girls," which premiered in 2011, chronicles the adventures of the Max Black (Kat Dennings) and Caroline Channing (Beth Behrs).
Starting this weekend Lohanwill star in an eight-episode reality showon Oprah Winfrey's OWN network. The series follows the actress as she moves back to New York after leaving rehab last year.
Earlier this week,CBS announcedthat Mila Kunis would be making a guest appearance on "Two and a Half Men" this season.
By Lauren Moraski, CBS News
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