The Hillsborough County Sheriff's Office says deputies were trying to pull over a Tahoe driven by Jason Fuflord near Fletcher Avenue.
They say he refused to stop, exited the interstate at Fowler, then re-entered going southbound in the northbound lanes.
Deputies stopped their chase, but Fulford hit two vehicles while trying to exit at Busch Boulevard.
No one was hurt.
Fulford tried to run, but deputies caught up with him.